Enalapril Maleate Loaded Pullulan Film for Mucoadhesive Buccal Drug Delivery Applications
نویسندگان
چکیده
Pullulan, a water soluble, bioadhesive and biocompatible biopolymer is used as an efficient matrix for enalapril maleate film preparation. The obtained film contains as much as 67% of enalapril maleate, relative to the initial amount used for experiments. The drug content was evaluated by using 1 H-NMR and UV-vis spectroscopy. The pullulanenalaprilmaleate blends exhibit good physicochemical properties, as well as a high dissolution rate, which makes these formulations usable as mucoadhesivebuccal film.
منابع مشابه
Formulation and Evaluation of Mucoadhesive Buccal Films of Enalapril Maleate
Enalapril maleate is used in the treatment of hypertension and angina pectoris. It shows low bioavailability due to high hepatic first pass metabolism. Hence the present work was undertaken to formulate mucoadhesive buccal films of enalapril maleate with an objective to improve therapeutic efficacy, patient compliance and the bioavailability. In the present study ten formulations of mucoadhesiv...
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